Non-antifungal drugs inhibit growth, morphogenesis and biofilm formation in Candida albicans
| Autor: | Gunderao Hanumantrao Kathwate, Ravikumar B. Shinde, S. Mohan Karuppayil |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pharmacology Drug biology 010405 organic chemistry Chemistry media_common.quotation_subject Antifungal drugs 030106 microbiology Biofilm Morphogenesis Germ tube Adhesion biology.organism_classification Antimicrobial 01 natural sciences 0104 chemical sciences Microbiology 03 medical and health sciences Drug Discovery Candida albicans media_common |
| Zdroj: | The Journal of Antibiotics. 74:346-353 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.1038/s41429-020-00403-0 |
| Popis: | The increased resistance/tolerance of Candida infections to antimicrobial treatment can be attributed to biofilm-associated cells. A way to overcome this situation is to re-purpose non-anti-fungal drugs that could be active against fungi. We have explored the potential of a small library of eighteen non-antifungal drugs used in different human diseases. Candida albicans was cultured in the presence and absence of different concentrations of these drugs. Subsequently, inhibition of growth, germ tube formation, adhesion, and biofilm development were studied. Out of eighteen drug molecules, six showed a reduction in planktonic and biofilm growth in a dose-dependent manner and three drugs inhibited germ tube formation. This study shows the potential of non-antifungal drugs for the development of new anti-Candida agents. |
| Databáze: | OpenAIRE |
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