Fatigue and its correlates in Indian patients with systemic lupus erythematosus
Autor: | Aman Sharma, John Michael Raj, Meenakshi Jolly, Benzeeta Pinto, Sandeep Grover, Aadhaar Dhooria |
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Rok vydání: | 2020 |
Předmět: |
030203 arthritis & rheumatology
medicine.medical_specialty Systemic lupus erythematosus business.industry General Medicine Stepwise regression medicine.disease Rheumatology 03 medical and health sciences 0302 clinical medicine Bodily pain Concomitant Internal medicine Fibromyalgia medicine Anxiety 030212 general & internal medicine medicine.symptom business Depression (differential diagnoses) |
Zdroj: | Clinical Rheumatology. 40:905-911 |
ISSN: | 1434-9949 0770-3198 |
Popis: | Fatigue is a disabling yet poorly understood symptom in patients with systemic lupus erythematosus (SLE). Many variables influence fatigue including physical function, pain, fibromyalgia and psychiatric comorbidity. Literature is conflicted on its association with disease activity. To assess fatigue and its correlates among patients with SLE. Existent data from validation of Hindi LupusPRO study were utilized for this study. SLE patients were enrolled and underwent assessments of disease activity and damage (SELENA-SLEDAI and SLICC/ACR Damage Index (SDI)). Depression (Patient Health Questionnaire-9 (PHQ-9)), anxiety (Generalized Anxiety Disorder-7 (GAD-7)), fatigue (Fatigue Severity Scale (FSS)) and fibromyalgia were evaluated. Physical function and bodily pain were assessed using Short Form 36 (SF-36). Statistical analysis was done using the STATA version 14. A total of 140 females and 4 males with SLE with a mean age of 32.48 (SD 7.26) years were recruited. Median duration of illness was 3 years (IQR-4). Fatigue (FSS ≥ 4) was present in 74 (51.39%) participants. Prevalence of depression (PHQ-9 ≥ 10) and anxiety (GAD-7 ≥ 10) were 25% and 22.9%, respectively. Concomitant fibromyalgia was present in 8 participants (5.56%). Higher fatigue scores correlated with greater disease activity, shorter disease duration, worse physical function, bodily pain, depression and anxiety. On stepwise regression, disease duration, disease activity, bodily pain, depression and anxiety were independent predictors of fatigue (R2 = 0.35, p |
Databáze: | OpenAIRE |
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