A Molecular Study of Solid Pseudopapillary Neoplasm of the Pancreas in a Pediatric Patient
| Autor: | Danielle FornyForny, Maria da Gloria da Costa Carvalho, Juliana de Saldanha da Gama Fischer, Vera Lucia Antunes Chagas, Marlon D.M. Santos, Bruna dos Santos Paiva Ribeiro, Paulo C. Carvalho, Fernando Colonna Rosman |
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| Rok vydání: | 2018 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry medicine.disease Proteomics Tumor heterogeneity Pathogenesis 03 medical and health sciences Pediatric patient 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Female patient medicine Neoplasm Immunohistochemistry 030211 gastroenterology & hepatology business Pancreas |
| Zdroj: | International Journal of Clinical Pediatrics. 7:63-68 |
| ISSN: | 1927-1263 1927-1255 |
| DOI: | 10.14740/ijcp320 |
| Popis: | Solid pseudopapillary neoplasm of the pancreas (SPNP) is considered as a tumor with low malignant potential. Little is known about how its molecular heterogeneity is involved in its pathogenesis. We aim to evaluate tumor heterogeneity by immunohistochemistry (IH) and proteomics in three macroscopically distinct areas. Tumor fragments were obtained from a 12-year-old female patient. We identified by mass spectrometry (MS) 1,427, 5,786, and 4,298 proteins for each sample, 1,337 being common to all fragments. Several MS results were immunohistochemically validated. Our results demonstrate unique intra-tumor protein profiles based on its heterogeneity. Int J Clin Pediatr. 2018;7(4):63-68 doi: https://doi.org/10.14740/ijcp320 |
| Databáze: | OpenAIRE |
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