Novel erythromycin A derivatives: synthesis of 11,12-benzoxazine ketolides

Autor:	Amy Maden, Mark J. Macielag, Bin Zhu
Rok vydání:	2005
Předmět:	Chemistry Stereochemistry Organic Chemistry Erythromycin Biochemistry chemistry.chemical_compound Derivative (finance) Intramolecular force Drug Discovery medicine Michael reaction Enone Ketolide medicine.drug
Zdroj:	Tetrahedron Letters. 46:1783-1785
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2005.01.126
Popis:	A novel series of 11,12-benzoxazine ketolide derivatives of erythromycin A has been synthesized. The C11,C12-benzoxazine structure was constructed stereoselectively through an intramolecular Michael addition of a C12- O -(2-aminophenyl) group to the enone functionality of the 10,11-anhydro erythromycin A derivative 3 .
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::65ce3637d38187f86342f3884adcb66e https://doi.org/10.1016/j.tetlet.2005.01.126 Zobrazit plný text záznamu Full Text from ScienceDirect