SERUM NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) AND URINARY NGAL EXCRETION AS A BIOMARKER OF RENAL INJURY IN CHILDREN WITH BETA THALASSEMIA MAJOR
| Autor: | Alok Hemal Dr, Zeeshan Ahmed Dr, Ruchi Bhatt Dr, Meetu Singh Dr |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
business.industry Urinary system 030232 urology & nephrology BETA THALASSEMIA MAJOR Gastroenterology Neutrophil gelatinase-associated lipocalin Excretion 03 medical and health sciences 0302 clinical medicine Renal injury Internal medicine medicine Biomarker (medicine) 030211 gastroenterology & hepatology business |
| Zdroj: | INDIAN JOURNAL OF APPLIED RESEARCH. :1-3 |
| DOI: | 10.36106/ijar/9602275 |
| Popis: | Background Frequent blood transfusions among patients with beta thalassemia major leads to iron overload state and leads to damage of various organs including kidney. Very few studies have explored on Serum and urinary NGAL as a biomarkers of renal injury in thalassemia major children. Therefore, this study is planned to investigate the renal injury in beta thalassemic children by measuring serum and urinary NGAL levels and correlating it with cystatin c and creatinine clearance. Methods: The study was a cross-sectional conducted among 25 patients with β thalassemia major, aged 1-18 years, having undergone regular blood transfusion and chelation therapy. Levels of plasma and urinary NGAL were measured and compared to the standard values of the normal range. Linear regression analysis was done. Results: Mean(SD) serum NGAL value in 1- 5 years of age was 1.6(0.26) , in 5-10 years was 2.15(0.23), in 10- 15 years was 2.6 (0.11) and > 15 years it was 18.11(33.76). ( p value 15 years it was 1.94(0.25). ( p value |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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