Hypercalcaemia following renal transplantation: A common problem of limited clinical consequence?
| Autor: | Randall J. Faull, Kym M. Bannister, Patrick Campbell Walker, Anthony R. Clarkson |
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| Rok vydání: | 2000 |
| Předmět: | |
| Zdroj: | Nephrology. 5:133-138 |
| ISSN: | 1440-1797 1320-5358 |
| DOI: | 10.1046/j.1440-1797.2000.00509.x |
| Popis: | SUMMARY: Tertiary hyperparathyroidism, manifesting as hypercalcaemia, is common after renal transplantation. It often resolves within the first few years, but in previous studies has been associated with bone, renal and cardiovascular pathology. There have been no large studies in the last 10 years, or in patients treated predominantly with Cyclosporin A, that have examined the long-term effect of this condition on patient or transplant outcomes. A retrospective analysis was conducted of 171 consecutive renal transplant recipients with at least 1 year of graft survival from 1984 to 1996. Measurement was made of current and past incidence of hypercalcaemia, the natural history of post-transplant hypercalcaemia, and its effect on graft survival and function, and patient mortality. The incidence of hypercalcaemia was 26% and did not change significantly during the time frame of the study. The average serum calcium increased until 6 months post-transplantation, and then steadily decreased over the next 7 years. There was a significant variation in the rate of decrease between subjects. No long-term effect on patient or graft survival or function was detected. Post-transplant hypercalcaemia usually represents a benign condition that resolves with time. A conservative approach is recommended in the management of most patients in this group. |
| Databáze: | OpenAIRE |
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