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Objective: To examine maternal serum levels of leptin at 11-13 weeks gestation in normal and pathological pregnancies. Methods: Serum leptin, PAPP-A and uterine artery pulsatility index (PI) at 11-13 weeks were measured in 480 singleton pregnancies, including 240 with normal outcome, 60 that subsequently developed preeclampsia (PE), 60 that developed Gestational Diabetes Mellitus (GDM), 60 that delivered Large for Gestational Age (LGA) neonates and 60 that delivered small(SGA) neonates. Regression analysis was used to determine factors affecting maternal serum leptin concentration and from this model each value was expressed as Multiples of the Median (MoM). The median MoM values in the outcome groups were compared. Results: In the normal group serum leptin levels increased with maternal weight and decreased with maternal height. In the PE group, the median leptin (1.18 MoM, p=0.027) and uterine artery PI (1.25 MoM, p |
