Application of tert-Butyl Disulfide-Protected Amino Acids for the Fmoc Solid-Phase Synthesis of Lactam Cyclic Peptides under Mild Metal-Free Conditions
| Autor: | Yanyan Guo, Jun Wang, Donald Bierer, Shuaishuai Sun, Yi-Ming Li, Jingnan Chen, Tingting Cui, Junyou Chen |
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| Rok vydání: | 2021 |
| Předmět: |
Tert butyl
chemistry.chemical_classification 010405 organic chemistry Organic Chemistry Disulfide bond 010402 general chemistry 01 natural sciences Combinatorial chemistry Cyclic peptide 0104 chemical sciences Amino acid chemistry.chemical_compound Solid-phase synthesis Metal free chemistry Lactam Molecule |
| Zdroj: | The Journal of Organic Chemistry. 86:8610-8619 |
| ISSN: | 1520-6904 0022-3263 |
| Popis: | Lactam cyclic peptides are a class of interesting and pharmaceutically active molecules, but their previous syntheses have required the use of heavy metals and/or forcing conditions. Here, we describe the efficient application of the previously reported tert-butyl disulfide-protected amino acids and their use in the efficient, solid-phase synthesis of a series of lactam cyclic peptides under mild, metal-free conditions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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