Anti-diabetic potential assessment of aqueous and ethanol extracts of arrow poison (Strophanthus hispidus) plant stem bark in Wistar male rats
| Autor: | M Ibrahim, I. O Onoagbe, M. Osibemhe |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Ethanol
medicine.diagnostic_test biology Chemistry medicine.medical_treatment Intraperitoneal injection Pharmacology medicine.disease biology.organism_classification Streptozotocin chemistry.chemical_compound Diabetes mellitus visual_art medicine visual_art.visual_art_medium Bark Strophanthus hispidus Lipid profile Plant stem medicine.drug |
| Zdroj: | Journal of Applied Sciences and Environmental Management. 23:603 |
| ISSN: | 1119-8362 |
| DOI: | 10.4314/jasem.v23i4.4 |
| Popis: | Diabetes mellitus is a chronic disease, for which there is no known cure except in some specific situation. The available orthodox drugs used for its management are having disadvantages. The aim of this study is to evaluate the anti-diabetic potential of aqueous and ethanol extracts of Strophanthus hispidus (SH) stem bark in Wistar male rats. Diabetes mellitus was induced by intraperitoneal injection of streptozotocin (55 mg/kg). Blood glucose concentrations, serum α-amylase and lipid profile of normal and diabetic rats were monitored for 12 weeks. The rats were treated with 250 mg/kg of aqueous and ethanol extracts of Strophanthus hispidus respectively. Dose-response study was also carried out. The results revealed significant (P |
| Databáze: | OpenAIRE |
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