Pulse Component Modification Detection in Spino Cerebellar Ataxia 2 Using ICA

Autor:	Roberto Becerra, Rodolfo V. García, Roberto Rodríguez, Luis Velázquez, Olga Valenzuela, Fernando Rojas, Jesús Gonz´lez
Rok vydání:	2011
Předmět:	Ataxia Cerebellar ataxia Pulse (signal processing) business.industry Significant difference Control subjects Independent component analysis Saccadic masking Component (UML) medicine Artificial intelligence medicine.symptom business Neuroscience
Zdroj:	Advances in Computational Intelligence ISBN: 9783642215001 IWANN (1)
DOI:	10.1007/978-3-642-21501-8_40
Popis:	Anomalies in the oculomotor system are well known symptoms in patients with severe Spino Cerebellar Ataxia 2 form of autosomal dominant cerebellar ataxias (ADCA), including the main parameters used to describe saccadic movements. Also a combination of a pulse and step components constitutes an accepted model of the saccadic generation system, In the present work, Independent Component Analysis (ICA) is used to separate both components, revealing a significant difference in the time of the pulse component to reach its maximum value. This result suggests its use in order to obtain a classification tool to diagnose this disease. Five electro-oculographic records of patients of SCA2 ataxia and five control subjects were processed with the ICA based algorithm with this objective.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::659c77873d62f71793461abb83420b36 https://doi.org/10.1007/978-3-642-21501-8_40 Zobrazit plný text záznamu