Two new apotirucallane-type isomeric triterpenoids from the root bark of Dictamnus dasycarpus with their anti-proliferative activity
| Autor: | Xing Jin, Xiao-Jing Wang, Wen-zhao Tang, Xian-hui Jia, Yunxue Zhao, Yuan-Yuan Bai |
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| Rok vydání: | 2014 |
| Předmět: |
Dictamnus dasycarpus
biology Chemistry Stereochemistry Limonin Apotirucallane Plant Science Anti proliferative biology.organism_classification Biochemistry chemistry.chemical_compound Triterpenoid Rutaceae visual_art visual_art.visual_art_medium Bark Agronomy and Crop Science Two-dimensional nuclear magnetic resonance spectroscopy Biotechnology |
| Zdroj: | Phytochemistry Letters. 10:118-122 |
| ISSN: | 1874-3900 |
| DOI: | 10.1016/j.phytol.2014.06.017 |
| Popis: | Two new apotirucallane-type isomeric triterpenoids, named as dictamnin A (1) and dictamnin B (2), with six limonoids, obacunone (3), limonin (4), rutaevin (5), 7 α -obacunyl acetate (6), fraxinellone (7), fraxinellonone (8), were isolated from the root bark of Dictamnus dasycarpus Turcz. (Rutaceae). Their structures were well determined by means of IR, MS, 1D and 2D NMR techniques. Both new apotirucallane-type isomeric triterpenoids displayed good antiproliferative effects on lung cancer cells A549 and resulted in a clear increase of the percentage of cells in G1 phase and a decrease in the percentage of cells in S and G2/M phases in comparison with control cells. |
| Databáze: | OpenAIRE |
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