Baker's yeast catalyzed asymmetric cycloaddition of nitrileoxides to CC bond : Improved chiral recognition by using β-cyclodextrin

Autor:	K. Rama Rao, N. Bhanumathi, P. B. Sattur
Rok vydání:	1990
Předmět:	chemistry.chemical_classification Cyclodextrin Chemistry Stereochemistry Organic Chemistry Optically active Biochemistry Cycloaddition Yeast Enzyme catalysis Catalysis Yield (chemistry) Drug Discovery Stereoselectivity
Zdroj:	Tetrahedron Letters. 31:3201-3204
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)94732-4
Popis:	Baker's yeast catalyzes for the first time the asymmetric cycloaddition reaction of arylsubstituted nitrileoxides 1 to vinylpyridines 2 to yield optically active 2-isoxazolines 3 . The stereoselectivity is enhanced by fixing the geometry of both dipole and dipolarophile by using β-cyclodextrin as an additional binding cavity along with Baker's yeast.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::658a3d200b6d7541aea0e5491a5e75ad https://doi.org/10.1016/s0040-4039(00)94732-4 Zobrazit plný text záznamu