1,2,4-Thiadiazol derivatives of cytisine alkaloid: solvate formation and phase transitions

Autor:	Kh. M. Shakhidoyatov, Bakhodir Tashkhodjaev, U. S. Makhmudov, L. Yu. Izotova, T. F. Ibragimov
Rok vydání:	2011
Předmět:	Thermogravimetric analysis Chemistry Stereochemistry Alkaloid General Chemistry Crystal structure Condensed Matter Physics Medicinal chemistry Crystal Cytisine chemistry.chemical_compound Phase (matter) Molecule Conformational isomerism Food Science
Zdroj:	Journal of Inclusion Phenomena and Macrocyclic Chemistry. 72:375-381
ISSN:	1573-1111 0923-0750
DOI:	10.1007/s10847-011-9993-7
Popis:	1,2,4-Thiadiazol derivatives of cytisine alkaloid—N-(3-methylthio-1,2,4-thiadiazol-5-yl-aminocarbonylmethyl) (1), N-(3-ethylthio-1,2,4-thiadiazol-5-yl-aminocarbonylmethyl) (2), N-(3-hexylthio-1,2,4-thiadiazol-5-yl-aminocarbonylmethyl) (3) cytisine have been crystallized from different solvents and by X-ray and TG–DSC method were studied. By X-ray analysis the structures of the crystal solvate of 2 with dioxane have been determined. By topology represented solvate belongs to tabulate type. In the crystal structure two conformers of the host molecules were determined. By TG–DSC method has been shown, that methyl-, ethyl-, and hexyl cytisine derivatives can exist in two phase forms. But, unlike methyl- and ethyl-derivatives, hexyl-derivative of cytisine not form inclusion compounds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::657755a100b9f6894ee2db3f27e72c9a https://doi.org/10.1007/s10847-011-9993-7 Full text from SpringerLink