Calcium alginate nanocarriers as possible vehicles for oral delivery of insulin
| Autor: | Shilpi Goswami, Anil Kumar Bajpai, Jaya Bajpai |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Materials science
Calcium alginate Insulin medicine.medical_treatment Biomedical Engineering Nanoparticle Bioengineering Nanotechnology Controlled release chemistry.chemical_compound chemistry medicine Particle General Materials Science Surface charge Nanocarriers Swelling medicine.symptom Nuclear chemistry |
| Zdroj: | Journal of Experimental Nanoscience. 9:337-356 |
| ISSN: | 1745-8099 1745-8080 |
| DOI: | 10.1080/17458080.2012.661472 |
| Popis: | In the present investigation, alginate nanoparticles have been prepared and characterised by various techniques such as FTIR, SEM, particle size analysis and surface charge measurements. It was found from both the SEM and particle size analysis that average size of the particle was about 40 nm. The particles were loaded with insulin and the release kinetics of insulin was studied in PBS medium. The results indicated that when percent loading increases from 11.7 to 38.9, the released amount of insulin increased from 18% to 60% of the loaded drug. The effect of composition of nanoparticles, pH and temperature of the release medium was examined on the amount of released insulin. It was observed when that amount of alginate in the feed mixture was varied from 1.0 to 2.0 g, the prepared nanoparticles showed a decreasing tendency to release insulin. Similarly, upon increasing the concentration of crosslinker in the range 0.5–1.1 mM, the release of insulin constantly decreased. The chemical stability of the load... |
| Databáze: | OpenAIRE |
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