Structural topology defines protective CD8 + T cell epitopes in the HIV proteome

Autor:	David R. Collins, Michael T. Waring, Gaurav D. Gaiha, Olivia Mae Waring, Todd M. Allen, Bruce D. Walker, Karen A. Power, Jonathan M. Urbach, Musie Ghebremichael, Daniel P Worrall, Elizabeth J. Rossin, James Chodosh, Itai Muzhingi, Chioma Nwonu, Melis N. Anahtar, Christian Landeros, Alicja Piechocka-Trocha, Ruchi M. Newman
Rok vydání:	2019
Předmět:	0301 basic medicine Multidisciplinary Immunogen T cell Human leukocyte antigen Biology Topology Epitope 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Immune system 030220 oncology & carcinogenesis medicine Cytotoxic T cell HIV vaccine CD8
Zdroj:	Science. 364:480-484
ISSN:	1095-9203 0036-8075
DOI:	10.1126/science.aav5095
Popis:	Structure-based immunogen design Vaccine design for highly mutable pathogens is hindered by a paucity of conserved immunogenic epitopes. Gaiha et al. employed a structure-based technique using network theory to assign scores to protein structure in order to infer mutational constraints (see the Perspective by McMichael and Carrington). The authors validated the method on proteins with published functional outcomes and then assessed mutational constraints within the HIV proteome. Highly networked residues strongly associated with immune control of HIV infection and may lead to protective immunogens for pathogens for which there is currently no efficient vaccine. Science , this issue p. 480 ; see also p. 438
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::656f08b8340c64078dc359cac0fda4b0 https://doi.org/10.1126/science.aav5095 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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