Plasma Beta-Endorphin Levels Before and After Relief of Cancer Pain
| Autor: | Mark V Boswell, Nabil Ail Elsheikh |
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| Rok vydání: | 2004 |
| Předmět: | |
| Zdroj: | Pain Physician. :67-70 |
| ISSN: | 2150-1149 1533-3159 |
| Popis: | BACKGROUND Plasma Beta endorphin (BE) is an endogenous peptide opioid derived form pro-opiomelanocortin. Although the role of plasma BE in pain regulation is unclear, plasma BE levels have been reported to correlate inversely with pain levels in cancer pain. OBJECTIVE To measure BE levels in patients with cancer before and after pain relief with different analgesic modalities, to evaluate the relationship between cancer pain, pain control and plasma BE levels. METHODS Prospective interventional study conducted in a university hospital setting. Patients with intractable pain due to upper abdominal visceral malignancies (pancreatic, liver and gastric cancers) agreed to participate in the study. Pain relief was provided with one of four primary modalities: 1) oral continuous release morphine, 2) thoracic epidural morphine boluses, 3) alcohol celiac plexus blocks or 4) interpleural infusions of bupivacaine. Blood samples for plasma BE levels were taken before treatment and at the time of maximal pain relief obtained with the particular treatment modality. Pain levels were determined using a 10 cm visual analogue scale. BE levels were measured by competitive radioimmunoassay using 125I Beta endorphin. RESULTS Average pain scores decreased from 7.3 +/- 1.27 (SD) before treatment to 1.2 +/- 1.18 (SD) after treatment (p |
| Databáze: | OpenAIRE |
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