Exploiting the Differential Reactivities of Halogen Atoms: Development of a Scalable Route to IKK2 Inhibitor AZD3264

Autor:	Sulur G. Manjunatha, Andiappan Murugan, Ravi Ramakrishnan, Sreekanth Bachu, Sridharan Ramasubramanian, Sudhir Nambiar, Vasantha Krishna Kadambar, Venkata Rao Torlikonda, Sajan George, Chandrasekhara Reddy
Rok vydání:	2014
Předmět:	Chemistry Organic Chemistry Halogen Scalability Organic chemistry Physical and Theoretical Chemistry Combinatorial chemistry Differential (mathematics)
Zdroj:	Organic Process Research & Development. 18:646-651
ISSN:	1520-586X 1083-6160
Popis:	An efficient and scalable synthesis of AZD3264 is described in which the differential reactivities of various halogen atoms have been employed. The process involves five linear chemical steps with three isolated stages starting from commercially available fragments.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::656e0fa44aadb749bb1d1366e80e5bf6 https://doi.org/10.1021/op500105n Zobrazit plný text záznamu