Efficacy and safety of misoprostol for intrauterine device insertion in women with no previous vaginal delivery
| Autor: | Ahmad Taher Masoud, Ahmed H. Ibrahim, Mai Ibrahim Sokkar, Ahmed M. Afifi, Hend G Abdelmageed, Ahmed M. Abbas, Ahmed Samy |
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| Rok vydání: | 2020 |
| Předmět: |
History
medicine.medical_specialty Vaginal delivery Obstetrics business.industry Pelvic pain Placebo Intrauterine device Computer Science Applications Education law.invention Randomized controlled trial law Strictly standardized mean difference Relative risk medicine medicine.symptom business Misoprostol medicine.drug |
| Zdroj: | Proceedings in Obstetrics and Gynecology. 10:2 |
| ISSN: | 2154-4751 |
| DOI: | 10.17077/2154-4751.1479 |
| Popis: | Introduction: The efficacy of misoprostol use for cervical priming before intrauterine device insertion (IUD) is controversial. This review aims to evaluate the evidence from published randomized controlled trials about the efficacy and safety of misoprostol before IUD insertion for pain relief in women with no previous vaginal delivery. Materials and methods: We searched the following electronic databases: Web of Science, Cochrane CENTRAL, SCOPUS, and PubMed for relevant studies using the following Mesh terms: (misoprostol) AND (intrauterine device OR IUD). The primary outcome was the mean pain score during insertion. Secondary outcomes included the ease of insertion score, the rate of successful IUD insertion, the rate of IUD insertion failure, and the adverse effects. Results: Ten randomized controlled trials (RCTs) (misoprostol: n=698 and placebo: n=689) were pooled in the analysis. The overall Standardized Mean Difference (SMD) of pain score did not favor either of the two groups (SMD= -0.09, 95%CI [-0.50, 0.33], p=0.007). Pooled results were highly heterogeneous (I2=93%, P |
| Databáze: | OpenAIRE |
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