Chitosan nanoparticles based nanovaccines for cancer immunotherapy
| Autor: | Yufen Zhao, Yong-Xiang Chen, Lei Shi, Zhi-Hua Huang, Yue Gao, Yan-Fang Liu, Zhan-Yi Sun, Pu-Guang Chen, Yan-Mei Li |
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| Rok vydání: | 2017 |
| Předmět: |
Chemistry
General Chemical Engineering medicine.medical_treatment 02 engineering and technology General Chemistry Chitosan nanoparticles 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Molecular biology Peptide antigen 0104 chemical sciences Immune system Cancer immunotherapy Cancer research medicine 0210 nano-technology |
| Zdroj: | Pure and Applied Chemistry. 89:931-939 |
| ISSN: | 1365-3075 0033-4545 |
| Popis: | Cancer immunotherapy based on tumor vaccine is very promising and intriguing for carcinoma treatment. Herein, antitumor nanovaccines consisting of self-assembled chitosan (CS) nanoparticles and two-component mucin1 (MUC1) glycopeptide antigens were reported. Two different kinds of polyanionic electrolyte [sodium tripolyphosphate (TPP) and γ-poly-L-glutamic acid (γ-PGA)] were combined with chitosan polymers to fabricate the diameter of nearly 400–500 nm CS nanoparticles by electrostatic interactions. The nanovaccines were constructed by physically mixing MUC1 glycopeptide antigens with CS nanoparticles, which reduced vaccine constructing complexity compared with traditional chemical total synthetic vaccines. Immunological studies revealed that the CS/γ-PGA nanoparticle could dramatically enhance the immunogenicity of peptide epitope and produce significantly high titers of IgG antibody which was even better than Freund’s adjuvant-containing vaccines. |
| Databáze: | OpenAIRE |
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