BENZYLATION OF BENZO[b]THIOPHENE USING ZnCl2-MODIFIED MONTMORILLONITE CLAY

Autor:	Peter D. Clark, S. T. E. Mesher
Rok vydání:	1995
Předmět:	Nitromethane Organic Chemistry Benzothiophene Biochemistry Catalysis Inorganic Chemistry Nitrobenzene chemistry.chemical_compound Montmorillonite Benzyl chloride chemistry Yield (chemistry) Thiophene Organic chemistry
Zdroj:	Phosphorus, Sulfur, and Silicon and the Related Elements. 105:157-162
ISSN:	1563-5325 1042-6507
DOI:	10.1080/10426509508042058
Popis:	Benzylation of benzo[b]thiophene (1) with benzyl chloride catalyzed by metal-doped K-10 montmoril-lonite clays is described. Whereas ZnQ2 dissolved in either nitromethane or nitrobenzene solution promoted benzylation of (1) only very slowly and resulted in a mixture of mono- and poly-substituted products, ZnCl2-modified K-10 resulted in rapid benzylation at - 17°C giving the 3-benzyl isomer in 74% isolated yield. This constitutes one of the most selective alkylations of (1) yet reported.
Databáze:	OpenAIRE
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