Association of Serum 25(OH)D Deficiency with High Viral Load in HBV Infected Patients
| Autor: | Nada Mohamed Hassan Amien, Ayman Ali Mohammed Alameen, Kashaf Junaid, Abualgasim Elgaili Abdalla, Mona O.A. Awadelkarim, Hind M. Siddig, Naser Eldin Bilal |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Pure and Applied Microbiology. 16:1643-1651 |
| ISSN: | 2581-690X 0973-7510 |
| Popis: | Hepatitis B virus (HBV) is a significant public health concern, particularly in low-income countries. The host immune response plays an essential role in hepatitis B virus outcome, mainly orchestrated by cytokines and immune modulators molecules such as vitamin D. This study aimed to determine the levels of cytokines (IL-10), interferon-gamma (IFN-gamma), interferon-lambada (IFN-lambada), granzyme B, and vitamin D in Khartoum, Sudan, and to assess the association between them and variable HBV viral load as well as liver enzyme levels. A total of 174 participants were enrolled in the trial, with 100 HBV-infected patients (who were HIV and HCV negative) and 74 healthy volunteers. Patients’ HBV viral load, vitamin D levels, liver enzymes, and circulatory cytokines were measured. This study revealed a remarkable decrease in vitamin D levels in HBV infected patients with an elevation in levels of liver biomarkers. The level of IL-10 was significantly higher in patients than in apparently healthy controls (p-value |
| Databáze: | OpenAIRE |
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