Structure-activity relationships of selected pyridines
| Autor: | Terry W Schultz, F M Applehans, G.W. Riggin |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Octanol
Hplc analysis Screening test Stereochemistry Health Toxicology and Mutagenesis Public Health Environmental and Occupational Health General Medicine Biology Pollution Persistence (computer science) Partition coefficient chemistry.chemical_compound Investigation methods chemistry Computational chemistry Tetrahymena pyriformis Toxicant |
| Zdroj: | Ecotoxicology and Environmental Safety. 13:76-83 |
| ISSN: | 0147-6513 |
| Popis: | Twenty 2- and 3-position derivatives of pyridine (C5H5N) were tested following a short-term static protocol. Biological activity was monitored as population growth of Tetrahymena pyriformis. These data were combined with previously reported data for twenty 4-position derivatives. Structure-activity relationships were examined using Kow as the physicochemical descriptor. These data form three linear models: one for the non-H-polar derivatives and two for the H-polar derivatives. The latter two models are parallel but have no obvious basis for a priori selectivity. HPLC analysis for toxicant persistence shows that only the smaller non-H-polar derivatives have any significant abiotic loss over the duration of the biological testing. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|