Synthesis and Biological Activity of 11,19-Bridged Progestins 11This paper is dedicated to Prof. R. Wiechert on the occasion of his 70th birthday
| Autor: | Klaus Schöllkopf, Peter Muhn, Rolf Krattenmacher, Karl-Heinrich Fritzemeier, Wolfgang Halfbrodt, Eckhard Ottow, Wolfgang Schwede, Günter Neef |
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| Rok vydání: | 1998 |
| Předmět: |
Pharmacology
animal structures urogenital system Chemistry Stereochemistry Organic Chemistry Clinical Biochemistry Biological activity Biochemistry Chemical synthesis Ovarian hormone Androgen Metabolism In vitro Endocrinology In vivo Progesterone metabolism polycyclic compounds Glucocorticoid metabolism Molecular Biology reproductive and urinary physiology hormones hormone substitutes and hormone antagonists |
| Zdroj: | Steroids. 63:166-177 |
| ISSN: | 0039-128X |
| DOI: | 10.1016/s0039-128x(97)00161-x |
| Popis: | A synthetic approach to 11,19-bridged progestins is described. The key step in the synthesis is a 6-endo-trig radical cyclisation. The new progestins were tested for their biological activities in vitro and in vivo and compared to those of known progestins. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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