Synthesis of (3-pyridyl)glyoxylic acid derivatives and their antimicrobial properties

Autor:	U. M. Azizov, K. F. Turchin, E. E. Mikhlina, V. A. Silin, L. N. Yakhontov, M. K. Nurullaeva
Rok vydání:	1986
Předmět:	Pharmacology NMR spectra database chemistry.chemical_compound Stereochemistry Chemistry Drug Discovery Carbon-13 Pyridine Proton NMR Carbon-13 NMR Ring (chemistry) Oxime Glyoxylic acid
Zdroj:	Pharmaceutical Chemistry Journal. 20:340-344
ISSN:	1573-9031 0091-150X
DOI:	10.1007/bf00758616
Popis:	The authors carry out a comparative study of chemical and biological characteristics of the structurally related compounds of several heteroarylglyoxylic acids to determine the influence of the heteroaromatic and, in particular, the basic pyridine ring on the properties of the alpha-oxo-acids. The authors synthesize (3-pyridyl)glyoxylic acid and study its chemical transformations. The structure of many of the compounds was confirmed by the /sup 1/H NMR spectra, and in the case of oxime the signals of the isomers were assigned on the basis of the /sup 13/C NMR spectrum of this compound, containing a /sup 15/N atom in the NOH group.
Databáze:	OpenAIRE
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