Effects of Gamma Radiation on the concentration of 5 Hydroxy L Tryptophan and 5 Hydroxytryptamine in presence of Radioprotector in Sprague Dawley Rats
| Autor: | Ashok Sharma, Sanjay Saini, K. K. Nagpal, Satyam Upadhyay |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Control level
Chemistry Hydrobromide Intraperitoneal route Mechanical Engineering General Chemical Engineering Lethal dose Biomedical Engineering General Physics and Astronomy Urine Pharmacology 5-Hydroxy-L-Tryptophan Computer Science Applications chemistry.chemical_compound Bromide Sprague dawley rats Electrical and Electronic Engineering |
| Zdroj: | Defence Science Journal. 47:383-388 |
| ISSN: | 0976-464X 0011-748X |
| DOI: | 10.14429/dsj.47.4021 |
| Popis: | The result of variation of 5-hydroxy-L-tryptophan (HT) and S-hydroxytryptamine (S-HT) in different tissues of control and gamma-irradiated Sprague Dawley rats with and without a radioprotector Beeta-amino-ethylisothiuronium bromide hydrobromide (AET) combination e.g. (HT + AET) have been studied. The retention of HT, in the tissues studied, decreased after lethal dose (10.5 Gy) but for 5-HT, no such trend was observed after incorporation of HT + AET. A slight tendency of both metabolites to come back to control level was also observed for Sprague Dawley rats. In urine, concentration of HT was less compared to 5-HT with a lethal dose (10.5 Gy). After incorporation of HT + AET the turnover rate of HT and 5-HT were found to be maximum when it was injected through intraperitoneal route. |
| Databáze: | OpenAIRE |
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