Chemical conjugation with cyclodextrins as a versatile tool for drug delivery
| Autor: | Rui Xia Zhang, Chang Cai Bai, Hui Min Chu, Qing Huang, Zhi Zhong Wang |
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| Rok vydání: | 2017 |
| Předmět: |
Drug
media_common.quotation_subject Chemical conjugation 02 engineering and technology General Chemistry Optically active 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound chemistry Covalent bond Drug delivery Nucleic acid Organic chemistry 0210 nano-technology DNA Food Science Conjugate media_common |
| Zdroj: | Journal of Inclusion Phenomena and Macrocyclic Chemistry. 89:29-38 |
| ISSN: | 1573-1111 1388-3127 |
| DOI: | 10.1007/s10847-017-0743-3 |
| Popis: | Cyclodextrins (CDs) are a well-known family of macrocyclic oligosaccharides consisted of α-(1, 4) linked glucose subunits, and have been generally used as mimetic enzymes, chiral reagents, sensors, excipients and drug delivery carriers, due to their hydrophobic and optically active interiors. A more recent interest focuses on the chemical conjugation of CDs with drugs, where a drug is covalently bonded to CDs with better physicochemical properties for controlled drug delivery. This contribution outlines the potential applications of the drug-CDs conjugates in different areas of drug delivery, particularly in peptides, proteins, and nucleic acids (DNA, RNA and gene) drug delivery. Finally, the future directions of research in this field are proposed. |
| Databáze: | OpenAIRE |
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