Visible light-activated biocompatible photo-CORM for CO-release with colorimetric and fluorometric dual turn-on response
| Autor: | Jingjing Liu, Patrick Hoffmann, Stefanie Gräfe, Helmar Görls, Alexander Schiller, Stephan Kupfer, Upendar Reddy Gandra, Johannes Steinmetzer, Sven H. C. Askes, Ute Neugebauer |
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| Rok vydání: | 2019 |
| Předmět: |
Fluorophore
010405 organic chemistry Ligand Corm 010402 general chemistry Biocompatible material Photochemistry 01 natural sciences 0104 chemical sciences Inorganic Chemistry Turn (biochemistry) chemistry.chemical_compound chemistry Materials Chemistry Molecule Physical and Theoretical Chemistry Co release Visible spectrum |
| Zdroj: | Polyhedron. 172:175-181 |
| ISSN: | 0277-5387 |
| DOI: | 10.1016/j.poly.2019.04.031 |
| Popis: | We introduce a colorimetric as well as fluorometric dual response CO-releasing molecule as Mn(I) tricarbonyl complex with a nitrobenzoxadiazole (NBD) fluorophore. DFT and TD-DFT studies corroborate that extended conjugation in the principal ligand frame will help to release CO at low energy radiation. A very low toxicity of NBD-CORM was observed against LX-2 and HepaRG® human cell lines. |
| Databáze: | OpenAIRE |
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