An efficient entry to highly substituted chiral 2-oxopiperazines from α-amino acids via iodocyclization

Autor:	Amit Kumar Jana, Sanjit Kumar Das, Gautam Panda
Rok vydání:	2012
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Stereochemistry Chemistry Amide Organic Chemistry Drug Discovery Wittig reaction Stereoselectivity Biochemistry Amino acid
Zdroj:	Tetrahedron. 68:10114-10121
ISSN:	0040-4020
DOI:	10.1016/j.tet.2012.09.109
Popis:	A short and stereoselective route for the synthesis of 2-oxopiperazines is presented starting from different naturally abundant α-amino acids. The key synthetic steps involved amide coupling, Wittig reaction, HWE olefination, aza-Michael reaction, iodocyclization. This new pathway involving first report of iodocyclization to construct chiral substituted 2-oxopiperazines furnished final compounds in good yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::653101669b3a1d4e8f5c699706c54128 https://doi.org/10.1016/j.tet.2012.09.109 Zobrazit plný text záznamu Full Text from ScienceDirect