| Autor: |
Fusako Sakai, Shoji Takeuchi, Yuya Morimoto, Saori Mori |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
2016 IEEE 29th International Conference on Micro Electro Mechanical Systems (MEMS). |
| DOI: |
10.1109/memsys.2016.7421612 |
| Popis: |
We propose a drug testing system for quantifying contractile frequency and force of fiber-shaped tissues of human iPS-derived cardiomyocytes in various drugs. By optimization of cell culture conditions for the cardiomyocytes fiber and dimensions of the PDMS devices with cantilevers, we succeeded in measurement of contractile frequency and force derived from deformations of the cantilevers. As a result of drug tests using our system, we achieved detection of changes of their contractile properties in accordance with physiological functions and reactions occurring in humans. Thus, we believe that the system using the fiber of human iPS-derived cardiomyocytes will be a useful tool in first-in-human pharmacokinetic studies for drug development. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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