Synthesis of spirothiohydantoin analogues of hydantocidin

Autor:	Masahiro Shindou, Shigeru Mio, Junko Kitagawa, Hiromi Sano, Honma Toyokuni, Soji Sugai
Rok vydání:	1995
Předmět:	Chemistry Stereochemistry Natural compound Organic Chemistry Drug Discovery Epimer Ring (chemistry) Biochemistry Hydantocidin
Zdroj:	Tetrahedron. 51:12563-12572
ISSN:	0040-4020
DOI:	10.1016/0040-4020(95)00810-u
Popis:	Synthesis of Spirothiohydantoin derivatives of hydantocidin is described. The key feature of the synthesis was Spirothiohydantoin ring formation through an iminophosphorane intermediate. Spirothiohydantoin derivative 2 maintained comparable herbicidal activity to that of the natural compound except against fall panicum, when applied through a foliage of weeds at 1000 ppm. Surprisingly, its epimer 15 also demonstrated good herbicidal activity under the same condition, while 5-epi-hydantocidin 16 displayed fair activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::652e0e8d0541b71765581893670e05bd https://doi.org/10.1016/0040-4020(95)00810-u Zobrazit plný text záznamu Full Text from ScienceDirect