Separate functions of α2β1 and α2β1 integrins in the metastatic process of human gastric carcinomaintegrins in the metastatic process of human gastric carcinoma

Autor:	Takahiro Yasoshima, Hideki Ura, Koichi Hirata, Ryuichi Denno, Koji Yamaguchi
Rok vydání:	1998
Předmět:	Pathology medicine.medical_specialty biology business.industry medicine.drug_class Integrin α3β1 integrin General Medicine medicine.disease Monoclonal antibody Metastasis medicine.anatomical_structure Surgical oncology Cancer cell biology.protein Medicine Surgery α2β1 integrin business Lymph node
Zdroj:	Surgery Today. 28:1001-1006
ISSN:	1436-2813 0941-1291
DOI:	10.1007/bf02483952
Popis:	The expression of α2β1 and α3β1 integrins was studied immunohistochemically in 110 resected human gastric carcinomas. Formalin-fixed and paraffin-embedded samples were serially sectioned and stained with monoclonal antibodies specifically against the α2 and α3 subunits of β1 integrins. Approximately 27% of the tumors expressed α3β1 integrin, and 20% expressed α3β1 integrin. The expression of α3β1 integrin was associated with lymph node and liver metastases (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6521ca3c28413e5ecf597daedb9988b3 https://doi.org/10.1007/bf02483952 Zobrazit plný text záznamu Full text from SpringerLink