A comparative view on the expression patterns of PD-L1 and PD-1 in soft tissue sarcomas

Autor: Martin F. Orth, Marion Subklewe, Thomas G. P. Grunewald, Eric Kampmann, Rolf D. Issels, Thomas Knösel, Thomas Kirchner, Laura Romero-Pérez, Elfriede Noessner, Fabienne S. Wehweck, Florencia Cidre-Aranaz, Annelore Altendorf-Hofmann, Veit Buecklein, Lars H. Lindner
Rok vydání: 2020
Předmět:
Zdroj: Cancer Immunology, Immunotherapy. 69:1353-1362
ISSN: 1432-0851
0340-7004
DOI: 10.1007/s00262-020-02552-5
Popis: Soft tissue sarcomas (STSs) are heterogeneous cancers associated with poor prognosis due to high rates of local recurrence and metastasis. The programmed death receptor ligand 1 (PD-L1) is expressed in several cancers. PD-L1 interacts with its receptor, PD-1, on the surface of tumor-infiltrating lymphocytes (TILs), thereby attenuating anti-cancer immune response. Immune checkpoint inhibitors targeting this interaction have been established as effective anti-cancer drugs. However, studies on the PD-L1 and PD-1 expression status in STS are commonly limited by small sample size, analysis of single STS subtypes, or lack of combinatorial marker assessment. To overcome these limitations, we evaluated the expression patterns of intratumoral PD-L1, the number of TILs, their PD-1 expression, and associations with clinicopathological parameters in a large and comprehensive cohort of 225 samples comprising six STS subtypes. We found that nearly all STS subtypes showed PD-L1 expression on the tumor cells, albeit with a broad range of positivity across subtypes (50% angiosarcomas to 3% synovial sarcomas). Co-expression and correlation analyses uncovered that PD-L1 expression was associated with more PD-1-positive TILs (P
Databáze: OpenAIRE
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