Bleeding and thrombosis in 55 patients with inherited afibrinogenaemia

Autor:	Flora Peyvandi, Elahi F, M. Lak, P. M. Mannucci, Keihani M
Rok vydání:	1999
Předmět:	medicine.medical_specialty Afibrinogenemia Vascular disease business.industry Hematology medicine.disease Haemophilia Thrombosis Surgery Congenital afibrinogenemia Coagulation medicine Coagulopathy business Complication
Zdroj:	British Journal of Haematology. 107:204-206
ISSN:	0007-1048
DOI:	10.1046/j.1365-2141.1999.01681.x
Popis:	Knowledge of the spectrum of symptoms in patients with inherited afibrinogenaemia is limited by the rarity of this coagulation defect. We compared a large series of 55 afibrinogenaemic patients from Iran with 100 patients with severe factor VIII deficiency. In afibrinogenaemia there was a higher frequency of mucosal-type bleeding symptoms but joint and muscle bleeding was less frequent and severe than in haemophilia. Umbilical cord bleeding was relatively frequent only in afibrinogenaemic patients. Two young patients developed spontaneous thrombotic episodes and three women had recurrent abortions. Overall, in afibrinogenaemia bleeding symptoms are qualitatively different and less severe than in haemophilia. Afibrinogenaemia can also be accompanied by thrombotic manifestations.
Databáze:	OpenAIRE
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