| Autor: |
Felix Horn, Jim M. Wild, Guilhem Collier, Neil J. Stewart, Matthew Q. Hatton, Graham Norquay, James A. Swinscoe, Paul Hughes, Helen Marshall, Kerry Hart, Rob H. Ireland, Bilal A Tahir |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
1.3 Imaging. |
| DOI: |
10.1183/13993003.congress-2016.pa744 |
| Popis: |
Introduction: Image registration of inspiratory & expiratory CT is a potential method of mapping regional ventilation assuming lung expansion & density changes of corresponding parenchymal voxels equates to ventilation. However, its physiological accuracy has yet to be validated against direct ventilation modalities such as hyperpolarised gas MRI. Objective: To compare the spatial correlation of ventilation CT & 3 He MRI in a cohort of lung cancer patients. Methods: 5 patients underwent expiration & inspiration breath-hold CT. 3 He & 1 H MRI were also acquired in the same breath and at the same inflation state as inspiratory CT. Expiration CT was deformably registered to inspiration CT for calculation of ventilation CT from voxel-wise differences in Hounsfield units. Inspiration CT was registered to 3 He MRI via the same-breath anatomical 1 H MRI to enable direct comparison of 3 He MRI & CT ventilation in corresponding regions of interest located within the lungs as defined by a 1 H MRI lung mask. Spearman coefficients were used to assess voxel-level correlation. Results: The median (range) Spearman9s coefficient was 0.68 (0.45-0.76). Conclusion : This work demonstrates a method of acquiring CT & 3 He MRI in similar breath-holds to enable direct spatial comparison of ventilation maps. Initial results show moderate correlation between ventilation CT & 3 He MRI, suggesting that ventilation CT may also be influenced by non-ventilatory factors. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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