Research Article Synergic effect of oral contraceptives, GSTP1 polymorphisms, and high-risk HPV infection in development of cervical lesions
| Autor: | Sergio Crovella, J.C. Silva Neto, S. S. L. Paiva Júnior, Antonio Victor Campos Coelho, Ana Pavla Almeida Diniz Gurgel, M. N. Cordeiro, Ronald Moura, Kamylla Conceição Gomes Nascimento, Bárbara Simas Chagas, Rita de Cássia Pereira de Lima, Antonio Carlos de Freitas |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Cervical cancer
Oncology medicine.medical_specialty business.industry virus diseases General Medicine medicine.disease Lesion 03 medical and health sciences GSTP1 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Internal medicine Genetics Genetic predisposition Population study Medicine Neoplastic transformation 030212 general & internal medicine Human papillomavirus medicine.symptom business Molecular Biology Cervix |
| Zdroj: | Genetics and Molecular Research. 16 |
| ISSN: | 1676-5680 |
| DOI: | 10.4238/gmr16039742 |
| Popis: | Human papillomavirus (HPV) infection is considered a risk factor for cervical cancer. Even if the high-risk HPV (HR-HPV) infection is necessary, environmental co-factors and genetic susceptibility also play an important role in cervical cancer development. In this study, a possible association of rs1695 GSTP1 polymorphisms, HR-HPV infection, and oral contraceptive use with cancer lesion development in women was investigated. The study population comprised 441 Brazilian women from the Northeast region including 98 HPV-infected women with high-grade squamous intraepithelial lesions, 77 HPV-infected women with low-grade squamous intraepithelial lesions, and 266 HPV-negative women with no lesion, used as a control. Our data did not show a significant association between the GSTP1 polymorphism A/G (rs1695) and any HPV-related cervical abnormalities. However, considering the use of oral contraceptives, the GSTP1 rs1695 polymorphism was associated with higher susceptibility to the development of cervical lesions in HR-HPV-infected women. Our study suggests a synergic effect of oral contraceptive use, GSTP1 polymorphisms, and HR-HPV infection in the development of cervical lesions. Together, these risk factors may induce neoplastic transformation of the cervical squamous epithelium, setting conditions for secondary genetic events leading to cervical cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|