Identification of HCV Inhibitors from a Cell-Based Sub-Genomic Replicon Screen

Autor:	Stephen M. Shaw, David C. Pryde, Thien Duc Tran, Chris Pickford, Caroline Smith-Burchnell, M. J. Gardner, Rob Webster, Satish Dayal, Mike Westby, Tanya Parkinson
Rok vydání:	2013
Předmět:	viruses Hepatitis C virus Cell Biology medicine.disease_cause Virology Subgenomic replicon medicine.anatomical_structure Genotype 1b Cell culture medicine Replicon Cytotoxicity Cell based
Zdroj:	Open Journal of Medicinal Chemistry. :16-25
ISSN:	2164-313X 2164-3121
Popis:	A high throughput screen of the Pfizer compound collection was carried out using a hepatitis C virus (HCV) genotype 1b subgenomic replicon cell line. Those confirmed hits that demonstrated broad spectrum activity without overt cytotoxicity were further evaluated, leading to the identification of a series of pyrrolopyridines with excellent antiviral activity in a fully infectious HCV cell-based assay and pharmacokinetic properties.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::64f90ed16816176de539d01a7b3fb97c https://doi.org/10.4236/ojmc.2013.31003 Zobrazit plný text záznamu