Synthesis and PAMPA Permeability Assay of New Sulfonyl Hydrazone Derivatives

Autor:	In ecirc, Moacir Geraldo Pizzolatti, Luiz Felipe de Souza, Larissa Sens, Dalila Venzke, Nunes, Tiago Tizziani, Ricardo Jos eacute, s Maria Costa Brighente
Rok vydání:	2019
Předmět:	chemistry.chemical_classification Sulfonyl Permeability (earth sciences) chemistry.chemical_compound chemistry Bioactive molecules Lipophilicity Hydrazone Biological activity Organic synthesis Combinatorial chemistry
Zdroj:	Journal of Biosciences and Medicines. :111-120
ISSN:	2327-509X 2327-5081
DOI:	10.4236/jbm.2019.79010
Popis:	This work describes the synthesis of seven new sulfonyl hydrazones, which were proposed from the general structure of acyl hydrazones and 2,4-dinitrosulfonamides. Sulfonyl hydrazones are a class of compounds known to exhibit a wide range of biological activity. In this sense, the study of the pharmacokinetic properties of the bioactive molecules is of extreme importance; therefore, in this article the permeability of these compounds with in vitro PAMPA assay mimetizing the permeability through the gastrointestinal tract as well as lipophilicity through miLogP was investigated. All compounds presented good permeability results; it was possible to make a structure-activity relationship with the obtained results and a comparison between the results.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::64f830fb5bd3a674ed4ab70120ed3042 https://doi.org/10.4236/jbm.2019.79010 Zobrazit plný text záznamu