Facteurs prédictifs et biomarqueurs de la pleurésie exsudative lymphocytaire tuberculeuse
| Autor: | O. Fikri, S. Ait Batahar, I. Ouldittou, Lamyae Amro, Imane Saidi, P.P. Koumeka |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Tuberculosis GeneXpert MTB/RIF biology business.industry Pleural effusion Gold standard (test) medicine.disease Gastroenterology respiratory tract diseases 03 medical and health sciences 0302 clinical medicine Adenosine deaminase 030228 respiratory system Internal medicine medicine biology.protein Biomarker (medicine) Histopathology 030212 general & internal medicine Risk factor business |
| Zdroj: | Revue des Maladies Respiratoires. 38:231-239 |
| ISSN: | 0761-8425 |
| DOI: | 10.1016/j.rmr.2020.11.001 |
| Popis: | INTRODUCTION Tuberculosis is the leading cause of exudative lymphocytic pleural effusion. OBJECTIVE To determine the predictive factors and assess the diagnostic performance of biomarkers for exudative lymphocytic tuberculous pleural effusion found in our practice. METHODS Case-control study from 01 January 2015 to 30 August 2019, including patients admitted to the day-hospital facility for pleural biopsy. Histopathology of pleural biopsy fragments was the gold standard for assessing the diagnostic performance of the biomarkers studied (pleural adenosine deaminase, geneXpert and pleural fluid culture). RESULTS One hundred and nine patients were included. The average age was 35.7±18.1 years. In all, 72.5% of them were diagnosed with tuberculosis. After multivariate analysis, only patients aged under 35 years old were found to be at risk for exudative lymphocytic tuberculous pleural effusion (adjusted odds ratio: 9.18 [1.99; 42.28], P=0.004). Histopathology was suggestive of tuberculosis in 84.8% of cases (P |
| Databáze: | OpenAIRE |
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