Anti-Candida Activity of Aroma Candy and Its Protective Activity Against Murine Oral Candidiasis

Autor:	Kunio Ezawa, Taiji Matsukawa, Motofumi Suzuki, Masatoshi Yamazaki, Akinobu Kishi, Kazumi Hayama, Shigeru Abe, Miki Takahashi, Nobuya Sato
Rok vydání:	2015
Předmět:	Traditional medicine biology Chemistry Propolis biology.organism_classification Citral Microbiology Corpus albicans chemistry.chemical_compound Infectious Diseases Cassia Polyphenol Oral microbiology Oligonol Aroma
Zdroj:	Medical Mycology Journal. 56:J23-J29
ISSN:	2186-165X 2185-6486
DOI:	10.3314/mmj.56.j23
Popis:	A daily eatable candy that has possible protective activity against oral candidiasis was experimentally produced. The candy was made from reduced-maltose as main constituent and from several natural products, such as oligonol (depolymerized polyphenols derived from lychee), cinnamon (cassia), citral, and capric acid, which are known to have anti-Candida activity in vitro and in vivo. The candy effectively inhibited the mycelial growth of C. albicans, even when it was diluted 1,000 times with culture media. We assessed the protective activity of the candy against murine candidiasis. When 50μl of candy dissolved and diluted 4 times with water was administered 3 times into the oral cavity of Candida infected mice, the score of lesions on the Candida-infected tongues improved on day 2. These findings suggest that this candy has potential as food that provides protective activity against oral candidiasis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::64eaa6af8cfcc4a2b1a31fe72e8d522e https://doi.org/10.3314/mmj.56.j23 Zobrazit plný text záznamu Plný text ve formátu PDF