Iron and inflammation: in vivo and post-mortem studies in Parkinson’s disease
| Autor: | Roberta J. Ward, Antonio Martin-Bastida, David T. Dexter, Sukhi Bansal, Bension S. Tilley, Steve M. Gentleman |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Parkinson's disease Grey matter Microgliosis Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Hepcidin Medicine Biological Psychiatry biology business.industry Pars compacta Neurodegeneration medicine.disease Ferritin Psychiatry and Mental health 030104 developmental biology medicine.anatomical_structure Neurology biology.protein Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neural Transmission. 128:15-25 |
| ISSN: | 1435-1463 0300-9564 |
| Popis: | In these present studies, in vivo and and post-mortem studies have investigated the association between iron and inflammation. Early-stage Parkinson’s disease (PD) patients, of less than 5 years disease duration, showed associations of plasmatic ferritin concentrations with both proinflammatory cytokine interleukin-6 and hepcidin, a regulator of iron metabolism as well as clinical measures. In addition ratios of plasmatic ferritin and iron accumulation in deep grey matter nuclei assessed with relaxometry T2* inversely correlated with disease severity and duration of PD. On the hand, post-mortem material of the substantia nigra compacta (SNc) divided according to Braak and Braak scores, III–IV and V–VI staging, exhibited comparable microgliosis, with a variety of phenotypes present. There was an association between the intensity of microgliosis and iron accumulation as assayed by Perl’s staining in the SNc sections. In conclusion, markers of inflammation and iron metabolism in both systemic and brain systems are closely linked in PD, thus offering a potential biomarker for progression of the disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink