Zirconium-catalysed direct substitution of alcohols: enhancing the selectivity by kinetic analysis

Autor:	Helena Lundberg, David Camaj, Robin Carlsson, Anja Ramström, Hernando Tuñon, Cristiana Margarita, Oscar Dalla-Santa, Malin Lill, Piret Villo
Rok vydání:	2021
Předmět:	Steric effects Zirconium chemistry Kinetic analysis Substitution (logic) chemistry.chemical_element Alkylation Selectivity Combinatorial chemistry Catalysis
Zdroj:	Catalysis Science & Technology. 11:7420-7430
ISSN:	2044-4761 2044-4753
DOI:	10.1039/d1cy01219c
Popis:	Kinetic analysis was used as a tool for rational optimization of a catalytic, direct substitution of alcohols to enable the selective formation of unsymmetrical ethers, thioethers, and Friedel–Crafts alkylation products using a moisture-tolerant and commercially available zirconium complex (2 to 8 mol%). Operating in air and in the absence of dehydration techniques, the protocol furnished a variety of products in high yields, including glycosylated alcohols and sterically hindered ethers. In addition, the kinetic studies provided mechanistic insight into the network of parallel transformations that take place in the reaction, and helped to elucidate the nature of the operating catalyst.
Databáze:	OpenAIRE
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