Thyroid Autotransplantation Following Total Thyroidectomy Restores Function in Mice

Autor: Daniel D Charous, Edmund A. Pribitkin, Ryan Heffelfinger, Jay L. Rothstein, Bryan T. Ambro, William M. Keane
Rok vydání: 2004
Předmět:
Zdroj: Otolaryngology–Head and Neck Surgery. 131
ISSN: 1097-6817
0194-5998
Popis: Problem: Total thyroidectomy (TT) is a procedure commonly performed for benign and malignant disease in the United States. Patients undergoing TT are frequently managed postoperatively with exogenous thyroxine or other thyroid supplementation to suppress the resulting increased TSH levels in the serum. Although thyroid hormone treatment can be effective in compensating for organ loss, patients continue to suffer from subclinical depression and weight gain. We hypothesized that reimplantation of functioning thyroid tissue could cure these patients by decreasing their need for exogenous thyroxine. Methods: To investigate this possibility, we performed TT in mice and established conditions to restore thyroid organs in hypothyroid animals. Results: We find that simultaneous or subsequent transplantation of 50% of a thyroid lobe into the sternocleidomastoid muscle (SCM) or subcutaneously provided adequate thyroid hormone levels in recipient mice. Serum samples, drawn preoperatively, and at weekly intervals for 5 to 7 weeks indicated that thyroid stimulating hormone levels rise to normal values 3 to 4 weeks following surgery. Histopathological analysis of thyroid transplants removed from the SCM indicated that 13 showed normal thyroid architecture. Conclusion: These data indicate that thyroid autotransplantation, where histocompatibilioty is not an issue, provides adequent thyroid function recovery in cases where thyroid hormone supplementation would otherwise be necessary. Significance: This procedure, performed using small amounts of healthy tissue and implantation into muscle, can be applied to conditions where small amounts of thyroid tissue are available. This procedure will provide reduced morbidity in patients undergoing TT. Support: None reported.
Databáze: OpenAIRE
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