| Autor: |
Benjamin Rinehart, Timothy M. Rambo, Aaron J. Miller, Brandon Foreman, Ulas Sunar, Dharminder S. Langri, Chien-Sing Poon |
| Rok vydání: |
2021 |
| Předmět: |
|
| DOI: |
10.1101/2021.11.11.21266071 |
| Popis: |
Recently proposed time-gated DCS (TG-DCS) has significant advantages compared to conventional CW-DCS, but it is still in an early stage and clinical capability has yet to be established. The main challenge for TG-DCS is the lower SNR when gating for the deeper travelling late photons. Longer wavelengths, such as 1064nm have a smaller effective attenuation coefficient and a higher power threshold in humans, which significantly increases the SNR. Here, we demonstrate the clinical utility of TG-DCS at 1064nm in a case study on a patient with severe traumatic brain injury admitted to the neuroscience intensive care unit (NSICU). We showed a significant correlation between TG-DCS early (ρ = 0.67) and late (ρ = 0.76) gated against invasive thermal diffusion flowmetry. We also analyzed TG-DCS at high temporal resolution (50 Hz) to elucidate pulsatile flow data. Overall, this study demonstrates the first clinical translation capability of the TG-DCS system at 1064nm using superconducting nanowire single photon detector. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
