| Popis: |
Background: So far no studies in Vietnam on the effects of Nattokinase on blood pressure. We implement the project to assess the effects of Nattokinase on blood pressure, markers of atherosclerosis, lipid profile. Subjects and methods: Subjects aged 18 to 70 years old was diagnosed with hypertension and pre-hypertension levels 1, randomly divided into two groups: group Nattokinase and placebo. Evaluate the atherosclerosis with index pulse wave velocity (PWV) and ankle-index forearm (ABI) by machine OMRON Office 1000 plus. Results: A total of 71 subjects, mean age 47.66 ± 9.37, in which 37 subjects Nattokinase group (92.50%), 34 subjects placebo group (85.00%) meet the 8-week study period research. Nattokinase reduce significantly the blood pressure in the time of 2 weeks, 4 weeks, 6 weeks, 8 weeks. (p 0.05). The urea and serum creatinine concentration, SGPT and SGOT no significant change (p> 0.05). Conclusion: Nattokinase NSK-SD had an effect to lower blood pressure after 8 weeks of treatment. Nattokinase also reduces the index atherosclerosis, lipid parameters before and after treatment. There were no complications and significant side effects by Nattokinase. It may be used in mild hypertension as a non-drug therapy combined with lifestyle change. Key words: Nattokinase, blood pressure, hypertension, pre-hypertension, arterial hypertension |
