Fréquences géniques des systèmes HPA-1 et HPA-2 et risque potentiel d’allo-immunisation dans une population tunisienne
| Autor: | S. Jemni Yacoub, B. Houissa, S. Abdelkefi, T. Chakroun, H. Romdhane, I. Jerray, M. Bouslama, I. Jedidi |
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| Rok vydání: | 2013 |
| Předmět: |
Genetics
endocrine system Pregnancy Potential risk Biochemistry (medical) Clinical Biochemistry Tunisian population Biology medicine.disease law.invention Genotype frequency law Immunology medicine Allele Allele frequency hormones hormone substitutes and hormone antagonists Polymerase chain reaction |
| Zdroj: | Immuno-analyse & Biologie Spécialisée. 28:115-119 |
| ISSN: | 0923-2532 |
| DOI: | 10.1016/j.immbio.2012.12.005 |
| Popis: | Summary Allele and genotype frequencies of HPA-1 and HPA-2 systems in a Tunisian population were determined by polymerase chain reaction with sequence-specific primers (PCR-SSP) in 100 volunteer blood donors. The risk of allo-immunization in these systems has subsequently been evaluated. This work shows a higher HPA-1b (0.195) and HPA-2b (0.150) allelic frequency, which can be responsible for the potential risk of allo-immunization in HPA-1 and HPA-2 systems in case of pregnancy or transfusion. |
| Databáze: | OpenAIRE |
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