Serum small-dense LDL abnormalities in chronic renal disease patients
| Autor: | Iris H.S. Chan, Angela Yee-Moon Wang, M. Chu, Shiu Hon Chui, Christopher W.K. Lam |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Microbiology (medical)
Nephrology medicine.medical_specialty Small dense ldl Very low-density lipoprotein Triglyceride business.industry Biochemistry (medical) Clinical Biochemistry Immunology Disease medicine.disease Microbiology Gastroenterology chemistry.chemical_compound Infectious Diseases chemistry Internal medicine medicine Immunology and Allergy lipids (amino acids peptides and proteins) Risk factor business Kidney disease Lipoprotein |
| Zdroj: | British Journal of Biomedical Science. 69:99-102 |
| ISSN: | 0967-4845 |
| DOI: | 10.1080/09674845.2012.12069133 |
| Popis: | Cardiovascular disease (CVD) is the principal cause of mortality in chronic kidney disease (CKD) patients. Dyslipoproteinaemia is a common metabolic derangement in CKD and a traditional risk factor for CVD. This study investigates serum lipoprotein, especially small-dense low-density lipoprotein (sd-LDL), abnormalities in CKD patients. A total of 131 CKD patients (age: 59 +/- 12 years, male = 64) diagnosed according to Kidney Disease: Improving Global Outcomes, 2004 (KDIGO) and 121 age- and gender-matched control subjects (age: 58 +/- 6 years, male = 62) were recruited from Hong Kong and Macau. Serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C) and direct LDL-C were assayed enzymatically. In addition, sd-LDL, together with very low density and intermediate-density lipoproteins (VLDL and IDL) were measured by US Food and Drug Administration (FDA)-approved polyacrylamide gradient gel electrophoresis. Compared to controls, CKD patients showed significantly decreased TC, LDL-C, normal-size LDL and HDL-C with increased TG, VLDL, IDL and sd-LDL (all P < 0.01). The increased sd-LDL and decreased normal-size LDL fractions resulted in a significantly elevated sd-LDL:LDL ratio in CKD (P < 0.005). In contrast to the low TC and LDL-C, sd-LDL and sd-LDL:LDL ratio were significantly elevated in CKD. Thus, sd-LDL will be used increasingly for CVD risk assessment in CKD and other diseases that show lipoprotein derangement. |
| Databáze: | OpenAIRE |
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