THE EFFECT OF GIVING PLANTAIN PEEL EXTRACT (Musa paradisiaca) ON MALONDIALDEHYDE LEVELS IN WISTAR RATS EXPOSED TO FILTER CIGARETTE SMOKE
| Autor: | null Satria Damarjati, null Lusiana Batubara, null Puspita Kusuma Dewi, null Amallia Nuggetsiana Setyawati |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Pharmaceutical Negative Results. 13:1118-1123 |
| ISSN: | 2229-7723 0976-9234 |
| Popis: | Background: Free radicals from filter cigarettes can contribute to the body's oxidative stress. Malondialdehyde is a substance that the body produces in response to oxidative stress. Antioxidants found in plantain peel extract can be used to counteract oxidative damage.Aim: This study sought to determine whether Wistar rats exposed to filtered cigarette smoke could have their MDA levels reduced by a plantain peel extract.Methods: On Wistar rats, this study used an actual experimental design with a post-test-only control group. Twenty-eight rats from the research sample were split into 4 separate groups. K+ received exposure to cigarette smoke, P1 received exposure to cigarette smoke and extracted at a dose of 200mg/kg BW, and P2 received exposure to cigarette smoke and extracted at a dose of 400mg/kg BW. K- serves as the negative control. K+ received exposure to cigarette smoke. The retroorbital plexus vein was used to draw blood from the dead rats afterward. MDA levels in the plasma were measured using the TBARS technique.Results: The average output of MDA levels in the K1, K2, P1, and P2 groups was 1.695 ppm, 2.430 ppm, 1.791 ppm, and 3.115 ppm, respectively. The K- and K+ groups showed a significant difference in the Mann-Whitney test (p=0.037), as did the K+ and P1 group (p=0.010), K+ and P2 group (p=0.025), and P1 and P2 group (p=0.004).Conclusion: MDA levels in Wistar rats exposed to filter cigarette smoke could be decreased by administering plantain peel extract. |
| Databáze: | OpenAIRE |
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