ChemInform Abstract: Synthesis and Biological Activity of Some 4-Amino-3-cinnolinecarboxylic Acid Derivatives. Part 5. Pyrimido[5,4-c]cinnolines and Triazepino[7,6-c]cinnoline

Autor:	Z. B. Ochocki, W. Pakulska, Andrzej Stańczak
Rok vydání:	2010
Předmět:	Dimethyl acetal Acetic anhydride chemistry.chemical_compound chemistry Organic chemistry Biological activity General Medicine Cinnoline
Zdroj:	ChemInform. 30
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199913179
Popis:	A series of substituted 3-aminopyrimido[5,4-c]cinnolines 3, 7 was prepared. 6,7-Substituted 4-amino-3-cinnolinecarboxylic acid 1 were condensed with acetic anhydride to give the respective 1,3-oxazino[5,4-c]cinnolines 2. The obtained derivatives reacted with hydrazines and gave 3-aminopyrimido[5,4-c]cinnolines. Reaction of the esters 5 with hydrazines produced hydrazides 6, which upon treatment with N,N-dimethylformamide dimethyl acetal gave 3-aminopyrimido[5,4-c]cinnolines 7. Treatment of 6b with bromocyan produced 2-amino-3,4-dihydro-3,10-dimethyl-5 H-1,3,4-triazepino[7,6-c]cinnolin-5-on (8b). Some of the synthesized compounds were screened for their effect on the CNS.
Databáze:	OpenAIRE
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