Synthesis and antimicrobial activity of chalcones containing benzotriazolylmethyl and imidazolylmethyl substituents

Autor:	T. N. Hung, V. A. Tarasevich, T. T. N. Hang, T. T. N. Mai, N. T. Nga, L. V. Chinh
Rok vydání:	2014
Předmět:	chemistry.chemical_compound Minimum inhibitory concentration Piperazine Benzotriazole chemistry Organic Chemistry Organic chemistry Imidazole Antimicrobial Ring (chemistry) Medicinal chemistry
Zdroj:	Russian Journal of Organic Chemistry. 50:1767-1774
ISSN:	1608-3393 1070-4280
DOI:	10.1134/s1070428014120094
Popis:	Methods have been developed for the synthesis of new 1H-benzotriazol-1-ylmethyl- and 1H-imidazol-1-ylmethyl-substituted chalcones starting from 2-hydroxyacetophenone. The procedures include chloromethylation, N-alkylation, and Claisen-Schmidt condensation. The presence of an imidazole fragment on the ring A and piperazine fragment on the ring B of the resulting chalcones increases their antimicrobial activity (minimum inhibitory concentration 12.5–50.0 μg/mL), whereas introduction of a benzotriazole fragment reduces the antimicrobial activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::64b0681d27260735154acfc1a7ce8d83 https://doi.org/10.1134/s1070428014120094 Zobrazit plný text záznamu Plný text ve formátu PDF