Fucoidanase inhibitory activity of phlorotannins from brown algae
| Autor: | Tatiana N. Zvyagintseva, Artem S. Silchenko, S. A. Fedoreev, Svetlana P. Ermakova, Vladimir V. Isakov, Tatiana I. Imbs |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
biology 010405 organic chemistry Costaria costata Chemistry Nuclear magnetic resonance spectroscopy biology.organism_classification Inhibitory postsynaptic potential 01 natural sciences 0104 chemical sciences law.invention Brown algae 03 medical and health sciences 030104 developmental biology Fucoidanase Biochemistry law Mole Recombinant DNA Agronomy and Crop Science Bacteria |
| Zdroj: | Algal Research. 32:54-59 |
| ISSN: | 2211-9264 |
| DOI: | 10.1016/j.algal.2018.03.009 |
| Popis: | The inhibitors of recombinant fucoidanase FFA2 from the marine bacterium Formosa algae KMM 3553T were found among the metabolites of brown algae Fucus evanescens and Costaria costata. NMR spectroscopy and mass spectrometry analysis showed that high molecular weight phlorethols (degree of polymerization (DP) of 12–25 monomers) from C. costata (ICc) and fucophloretol (DP = 3) from F. evanescens (IFe) were inhibitors of fucoidanase. To inhibit one mole of FFA2 fucoidanase about two molecules of the ICc inhibitor or 7 molecules of the IFe inhibitor are needed. It has been suggested that the effectiveness of inhibition increases with the increasing molecular weight of phlorotannins. An irreversible type of inhibition was established. |
| Databáze: | OpenAIRE |
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